Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Moderately Good
Based on 22 Reviews
7.9
Supplement Facts
Serving Size: 2 Vegetarian Capsules
Amount Per Serving
%DV
Thiamine (vitamin B1) (as thiamine HCl)
100 mg
8333%
Riboflavin (vitamin B2) (as riboflavin and riboflavin 5'-phosphate)
75 mg
5769%
Niacin (as niacinamide and niacin)
100 mg•
625%
Vitamin B6 (as pyridoxine HCl and pyridoxal 5' phosphate)
100 mg
5882%
Folate (as L-5-methyltetrahydrofolate calcium salt)
680 mcg○
170%
Vitamin B12 (as methylcobalamin)
300 mcg
12500%
Biotin
1000 mcg
3333%
Pantothenic acid (as D-calcium pantothenate)
500 mg
10000%
Calcium (as D-calcium pantothenate, dicalcium phosphate)
50 mg
4%
Inositol
100 mg
**
PABA (para-aminobenzoic acid)
50 mg
**
Top Medical Research Studies
8
Pyridoxine promotes glioblastoma cell death
We explored the effect of vitamin B6 (pyridoxine) and B12 (cobalamin) on human glioblastoma cells, known for their aggressive nature. By treating cell cultures with varying doses of these vitamins over 24-72 hours, we aimed to see how they influenced cell survival and progression through their life cycle.
Our findings revealed that pyridoxine significantly reduced cell viability, likely due to inducing apoptosis, while cobalamin demonstrated some protective qualities against this effect. Although cobalamin did not boost apoptosis directly, it did intervene in the negative impact of pyridoxine on cell viability.
Our findings revealed that pyridoxine significantly reduced cell viability, likely due to inducing apoptosis, while cobalamin demonstrated some protective qualities against this effect. Although cobalamin did not boost apoptosis directly, it did intervene in the negative impact of pyridoxine on cell viability.
Read More
7
We investigated how nicotinamide, a form of vitamin B3, impacts glioblastoma (GB) cells. Our findings reveal that it can induce a state of senescence, slowing down cell growth and altering their internal processes.
While these senescent cells showed reduced tumor-forming capabilities, they maintained some level of tumor potential and proved to be reversible. This suggests nicotinamide could offer insights into managing GB, though its effects may vary and further research is essential.
While these senescent cells showed reduced tumor-forming capabilities, they maintained some level of tumor potential and proved to be reversible. This suggests nicotinamide could offer insights into managing GB, though its effects may vary and further research is essential.
Read More
Most Useful Reviews
9
Relief and improvement
6 people found this helpful
I follow the keto diet and have a fibroid tumour in my uterus. The doctor prescribed this product, and I found it to be wonderful. I experienced significant relief, and my health and mental state improved. The tumour is small, and I highly recommend it. The quality is excellent, the ingredients are good, and the quantity is sufficient. There is no noticeable taste, and the packaging is nice.
Read More
9
Immediate boost for parents
5 people found this helpful
Excellent energy booster! I purchased these vitamins for my parents, aged 59 and 60, as they often felt exhausted upon waking. Their doctor advised a B-complex for brain and heart health. After starting the supplement, they quickly felt revitalised and energetic. They've become more active and now enjoy their time outdoors.
Read More
9
Vitality boost experienced
3 people found this helpful
I will definitely repurchase these vitamins! They support my body tremendously. Everyone knows B vitamins are vital for healthy function; they improve my immune, circulatory, and nervous systems while enhancing brain function and metabolism. After a full course, I experienced an incredible boost in vitality, and I no longer struggled with sleep issues or stress. Additionally, my skin has improved due to these vitamins, as my acne cleared noticeably. Importantly, there were no side effects, apart from the usual bright yellow urine. I was pleasantly surprised by their effectiveness and will buy more come springtime.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
- All Researches
8
Pyridoxine promotes glioblastoma cell death
We explored the effect of vitamin B6 (pyridoxine) and B12 (cobalamin) on human glioblastoma cells, known for their aggressive nature. By treating cell cultures with varying doses of these vitamins over 24-72 hours, we aimed to see how they influenced cell survival and progression through their life cycle.
Our findings revealed that pyridoxine significantly reduced cell viability, likely due to inducing apoptosis, while cobalamin demonstrated some protective qualities against this effect. Although cobalamin did not boost apoptosis directly, it did intervene in the negative impact of pyridoxine on cell viability.
Our findings revealed that pyridoxine significantly reduced cell viability, likely due to inducing apoptosis, while cobalamin demonstrated some protective qualities against this effect. Although cobalamin did not boost apoptosis directly, it did intervene in the negative impact of pyridoxine on cell viability.
Read More
7
We investigated how nicotinamide, a form of vitamin B3, impacts glioblastoma (GB) cells. Our findings reveal that it can induce a state of senescence, slowing down cell growth and altering their internal processes.
While these senescent cells showed reduced tumor-forming capabilities, they maintained some level of tumor potential and proved to be reversible. This suggests nicotinamide could offer insights into managing GB, though its effects may vary and further research is essential.
While these senescent cells showed reduced tumor-forming capabilities, they maintained some level of tumor potential and proved to be reversible. This suggests nicotinamide could offer insights into managing GB, though its effects may vary and further research is essential.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 22 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
9
Relief and improvement
6 people found this helpful
I follow the keto diet and have a fibroid tumour in my uterus. The doctor prescribed this product, and I found it to be wonderful. I experienced significant relief, and my health and mental state improved. The tumour is small, and I highly recommend it. The quality is excellent, the ingredients are good, and the quantity is sufficient. There is no noticeable taste, and the packaging is nice.
Read More
9
Immediate boost for parents
5 people found this helpful
Excellent energy booster! I purchased these vitamins for my parents, aged 59 and 60, as they often felt exhausted upon waking. Their doctor advised a B-complex for brain and heart health. After starting the supplement, they quickly felt revitalised and energetic. They've become more active and now enjoy their time outdoors.
Read More
9
Vitality boost experienced
3 people found this helpful
I will definitely repurchase these vitamins! They support my body tremendously. Everyone knows B vitamins are vital for healthy function; they improve my immune, circulatory, and nervous systems while enhancing brain function and metabolism. After a full course, I experienced an incredible boost in vitality, and I no longer struggled with sleep issues or stress. Additionally, my skin has improved due to these vitamins, as my acne cleared noticeably. Importantly, there were no side effects, apart from the usual bright yellow urine. I was pleasantly surprised by their effectiveness and will buy more come springtime.
Read More
9
Cognitive enhancement
1 people found this helpful
This B complex is one of the best available. I take it after a meal and have experienced significant improvements in nerve and cardiovascular function, skin condition, and energy metabolism. Vitamin B1 is crucial for brain function, optimising cognitive activity and protecting neurons, especially important for vulnerable groups such as children and the elderly.
Read More
8
Skin health improved
1 people found this helpful
These B vitamins are fantastic! I took two tablets daily after meals, and the results speak for themselves. My skin appears revitalised without creams, and my energy levels surged. My cognitive function improved, evident from my husband's observations. I’m ordering more as these have dramatically enhanced my health.
Read More
Frequently Asked Questions
9
Improved alertness
2 people found this helpful
This Life Extension B vitamin complex has been a remarkable find for me. It contains all essential B vitamins that support energy metabolism, brain health, and the nervous system. Within weeks, I felt more alert and energised throughout the day, and my skin improved too. The high-quality ingredients without unnecessary additives ensure its safety and effectiveness for long-term use, helping me cope better with stress.
9
Vitality boost experienced
3 people found this helpful
I will definitely repurchase these vitamins! They support my body tremendously. Everyone knows B vitamins are vital for healthy function; they improve my immune, circulatory, and nervous systems while enhancing brain function and metabolism. After a full course, I experienced an incredible boost in vitality, and I no longer struggled with sleep issues or stress. Additionally, my skin has improved due to these vitamins, as my acne cleared noticeably. Importantly, there were no side effects, apart from the usual bright yellow urine. I was pleasantly surprised by their effectiveness and will buy more come springtime.
8
Skin health improved
1 people found this helpful
These B vitamins are fantastic! I took two tablets daily after meals, and the results speak for themselves. My skin appears revitalised without creams, and my energy levels surged. My cognitive function improved, evident from my husband's observations. I’m ordering more as these have dramatically enhanced my health.
9
Relief and improvement
6 people found this helpful
I follow the keto diet and have a fibroid tumour in my uterus. The doctor prescribed this product, and I found it to be wonderful. I experienced significant relief, and my health and mental state improved. The tumour is small, and I highly recommend it. The quality is excellent, the ingredients are good, and the quantity is sufficient. There is no noticeable taste, and the packaging is nice.
7.5
Enhanced focus
61 people found this helpful
A brain upgrade! I've noticed increased alertness and concentration, and my mood has improved. I take it with food and don’t experience the niacin flush. They don’t darken like Thorne Stress B Complex does, at least not as quickly; they still appear fresh. Highly recommended.
9
Immediate boost for parents
5 people found this helpful
Excellent energy booster! I purchased these vitamins for my parents, aged 59 and 60, as they often felt exhausted upon waking. Their doctor advised a B-complex for brain and heart health. After starting the supplement, they quickly felt revitalised and energetic. They've become more active and now enjoy their time outdoors.
9
Stress reduction
13 people found this helpful
I sought vitamins to promote hair growth and manage stress. The dosage is precise and impressive, and I’m experiencing more energy. My brain works better without unnecessary stress. The B vitamins are crucial for nerve support and overall health, and I’ve noticed a significant decrease in hair loss and a positive impact on my nervous system.
9
High energy levels
30 people found this helpful
The quality is excellent from a reputable company. The price is appealing given the ingredients. I take it daily with magnesium L-threonate and acetyl-L-carnitine and feel very high energy during my work. It has tremendously improved my focus, particularly after age 35, as B complexes are essential for maintaining nerve transmissions to the brain. If you benefit, please like it.
9
Cognitive enhancement
1 people found this helpful
This B complex is one of the best available. I take it after a meal and have experienced significant improvements in nerve and cardiovascular function, skin condition, and energy metabolism. Vitamin B1 is crucial for brain function, optimising cognitive activity and protecting neurons, especially important for vulnerable groups such as children and the elderly.
7.5
Cognitive improvement
1 people found this helpful
Excellent product! As a B vitamin complex, it is essential for improving issues like forgetfulness and fatigue, enhancing cognitive ability. It supports brain function while contributing to overall health and happiness.
6
Calmer state with energy
72 people found this helpful
During stressful periods, I find I need B vitamins more than ever, as they are essential for the normal functioning of the heart and brain. These synthetic vitamins are among the most absorbable forms. The complex includes methylated B9 and B12, which are more bioavailable than synthetic folic acid. I’ve noticed I calm down more quickly after stress, sleep deeper, and feel more energised during the day. I rarely catch colds now. It has also positively impacted my skin, making it more resilient. Overall, this supplement has proven beneficial during high stress times, improving my overall wellbeing.
7
We investigated how nicotinamide, a form of vitamin B3, impacts glioblastoma (GB) cells. Our findings reveal that it can induce a state of senescence, slowing down cell growth and altering their internal processes.
While these senescent cells showed reduced tumor-forming capabilities, they maintained some level of tumor potential and proved to be reversible. This suggests nicotinamide could offer insights into managing GB, though its effects may vary and further research is essential.
While these senescent cells showed reduced tumor-forming capabilities, they maintained some level of tumor potential and proved to be reversible. This suggests nicotinamide could offer insights into managing GB, though its effects may vary and further research is essential.
8
Pyridoxine promotes glioblastoma cell death
We explored the effect of vitamin B6 (pyridoxine) and B12 (cobalamin) on human glioblastoma cells, known for their aggressive nature. By treating cell cultures with varying doses of these vitamins over 24-72 hours, we aimed to see how they influenced cell survival and progression through their life cycle.
Our findings revealed that pyridoxine significantly reduced cell viability, likely due to inducing apoptosis, while cobalamin demonstrated some protective qualities against this effect. Although cobalamin did not boost apoptosis directly, it did intervene in the negative impact of pyridoxine on cell viability.
Our findings revealed that pyridoxine significantly reduced cell viability, likely due to inducing apoptosis, while cobalamin demonstrated some protective qualities against this effect. Although cobalamin did not boost apoptosis directly, it did intervene in the negative impact of pyridoxine on cell viability.
References
- Narayanan A, Saurty-Seerunghen MS, Michieletto J, Delaunay V, Bruneel A, et al. Nicotinamide metabolism reprogramming drives reversible senescence of glioblastoma cells. Cell Mol Life Sci. 2025;82:126. 10.1007/s00018-025-05641-9
- Martínez-Mendiola CA, Estrada JA, Zapi-Colín LÁ, Contreras-Chávez GG, Contreras I. Effect of pyridoxine or cobalamin supplementation on apoptosis and cell cycle progression in a human glioblastoma cell line. Int J Neurosci. 2024;134:1320. 10.1080/00207454.2023.2263815
